Here is a list of patents granted to us as a result of our research.

 

CHROMA PATENT portfolio

Collyrium Composition and Method of Using Same

Patent number: US 9,585,908  
Issue Number: Mar 7, 2017  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.

Description: Combustion reactions release pollutant gases that associate with ocular fluids and tissues which can have an acute ocular impact. The chronic irritation and chemical effects of these gases also promote ocular aging over the lifespan. Instantaneous pollutant effects can be reduced at the time of eye exposure by using an eyewash (collyrium) composition comprising hydroxocobalamin and/or hydroxo(aquo)cobalamin. Such compositions minimize pollutant gas reactions with ocular tissues by (1) deactivating the gases; and (2) expediting their removal from the eye by, for example, aqueous rinsing and dilution.

Synthesis of high molecular weight iron-saccharidic complexes

Patent number: US 8,691,776  
Issue Number: Apr 8, 2014  
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Inventors: Robert A. Beck, Robert A. Mateer Jr., John Kowalski

Description: A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH).sup.- ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i):(ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e.g., lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 8,460,939  
Issue Number: Jun 13, 2014  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.

Description: A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions, including those useful for the treatment of humans and animals.

Synthesis of high molecular weight iron-saccharidic complexes

Patent number: US 7,964,568   
Issue Number: Jun 21, 2011  
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Inventors: Robert A. Beck, Robert A. Mateer Jr., John Kowalski

Description: A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH).sup.- ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i): (ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e.g., lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.

Method for producing purified hematinic iron-saccharadic complex and product produced

Patent number: US 7,883,897  
Issue Number: Feb 8, 2011  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.

Description: Method for producing purified hematinic iron-saccharadic complex and product produced

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 7,687,273  
Issue Number: Mar 30, 2010  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.

Description: Method for producing purified hematinic iron-saccharidic complex and product produced

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 6,939,715  
Issue Number: Sep 6, 2005  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.
Description: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 6,929,954  
Issue Number: Aug 16, 2005  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.
Description: A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions.

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 6,773,924  
Issue Number: Aug 10, 2004  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.
Description: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

Method for producing purified hematinic iron-saccharidic complex and product produced

Patent number: US 6,537,820  
Issue Number: Oct 31, 2001  
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Inventors: Robert A. Beck, Robert A. Mateer Jr.
Description: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.