We are proud of our analytical talents supporting product development initiatives funded by the Contraceptive Research and Development (CONRAD) Program and the University of Eastern Virginia Medical School, the Bill and Melinda Gates Foundation (AIDS intervention drug development), Santen Pharmaceuticals (ophthalmic fluid development), BioTime, Inc. (hydroxyethylated starch (HES) based plasma expanders and stem cell culture media development for regenerative medicine), SAIC/NCI, the U.S. Agency for International Development (USAID), Rush University Presbyterian Medical Center (microbicides), the U.S. Geological Survey (humic acid characterization), InterMune Inc. (interferon characterization), Alpha Industries Inc., Elan Pharmaceuticals (anticancer drugs), Mentor Corporation, Glycogenesis (anticancer initiatives for pancreatic malignancies), Millipore Corporation, ALZO Corp., Ivex Novacel, Johnson & Johnson Inc. (transmucosal drug delivery systems, Anteis S. A. (implantable medical devices, dermal fillers), Merz Pharma,  and many others.

 

RESEARCH

DERMAL FILLERS USED IN AESTHETIC MEDICINE

Dermal fillers and viscoelastic injectables are used to smooth out and create volume in skin areas that become aged and wrinkled over time. They rely on a variety of substances such as collagen, hyaluronic acid and other materials both naturally-occurring, man-made, or derivatized from natural polymers. These products can be used to plump lips, smooth out wrinkles on the forehead or around the face. The manufacturing properties of injectable dermal fillers rely on uniquely controlled polymeric molecular weights, with/or without  cross-linking agents,  and with/or without mineral adjuncts or synthetic acid polymers to increase underlying tissue volumes associated with facial wrinkles or nasolabial folds.

CAT provides an analytical LC-MALLS resource for industry leaders who manufacture dermal fillers and strive to improve the functionality and uniformity of their injectable products. Properties of these injectable viscoelastic gel products offer analytical hurdles that challenge ordinary chromatography methods. Nonetheless, CAT has developed proprietary protocols that reproducibly characterize these medical devices and ensure consistent dermal filler manufacturing and performance.

INTRAVENOUS IRON NANOPARTICLES FOR IRON REPLACEMENT (IRT) THERAPIES

involving iron deficiencies due to chronic kidney disease,  routine kidney dialysis, and certain cancers. (U.S. Patents 6,537,820; 6,773,924; 6,929,954 and 7,687, 273. This initiative improves the analytical surveillance of nanoparticles in the interest of quality, uniformity, and safety. Additional IP aids the improved manufacturing of therapeutic iron nanoparticles for many other uses.

UNPRECEDENTED TRACE FORENSIC DETECTION

and characterization of post-explosion byproducts and firearm discharges. The purpose of this program is to gather distribution data and map detonation evidence for certain known or unknown materials

RENEWABLE ENERGY TECHNOLOGIES

and new energy transfer concepts for solar and  electrical energy sources.

MYCOTOXINS IN GRAINS AND CANINE SEIZURES

Due to the challenges of storing corn and other grains, mycotoxin threats to grain quality are near all-time highs. Environmental conditions before and after grain storage are key factors affecting mycotoxin levels in grain stockpiles. Mold toxins like aflatoxins B1, B2, G1 and G2 plus other metabolites due to mold growth are common features of natural human foods including dried fruits (e.g., apricots, figs), peanuts and tree nuts,  fermented sauces, dried herbage, spices,  and other foodstuffs. Dried imported foods are roundly incriminated with evidence of mycotoxins.  CAT has worked to routinely improve mycotoxin screening methods for human foods at risk for developing aflatoxins plus other mold metabolites.

 

CHROMA PATENTs

Our most recent patent is granted to us as of March 7, 2017.

Collyrium Composition and Method of Using Same

Patent number: US 9,585,908  
Issue Number: Mar 7, 2017

See our complete patent portfolio here.